Monoclonal Antibody Services

Looking for a partner who can generate the exact monoclonal antibody you need, not impose a predefined package?

CER Groupe develops fully custom monoclonal antibodies, starting from your target and application. You tell us what you need the antibody to do; we design the strategy, select the most relevant species, and coordinate immunisation, screening, cloning and production steps.

Our ISO9001-certified infrastructure combines in‑house animal facilities, screening technologies, recombinant expression options and application-oriented characterisation. And because our model is 100% fee‑for‑service, you always retain full IP and full freedom of use.

Why Choose CER Groupe?

Tailored strategy — never pre‑packaged

We define with you the best combination of species, screening depth and production route, ensuring your monoclonal antibody fits your application.

One integrated site

Mouse, rat and rabbit immunisations
Hybridoma or rabbit B‑cell workflows
Recombinant expression possibilities
Purification, conjugation & freeze‑drying
Scale-up & preclinical support via dedicated pages

Full IP for the client

We do not retain any intellectual property on antibodies generated for you. You own everything — sequence, clone, materials, data.

Diagnostic & biotech‑ready

Our antibodies support ELISA, LFA, CLIA, cell‑based assays, research workflows, and upstream preclinical stages (in vitro/in vivo testing via other CER services).

Monoclonal Antibody Development Workflow

Below is an example of a typical monoclonal project workflow, with indicative durations, key testing points and deliverables. Exact timelines depend on target complexity and species.

1. Project Definition & Antigen Strategy (1–2 weeks)

Goal : Build the right plan around your target & application. What we do together :

Confirm antigen format and specifications
Define species: mouse, rat or rabbit
Select screening depth (number of candidates & assays)
Choose between hybridoma or rabbit B‑cell workflow
Define deliverables, timelines and budget

Deliverables :

Custom project plan
Antigen & species recommendation
Optional antigen production proposal

2. Immunisation Phase (6–10 weeks)

What we do :

Immunise animals with your antigen
Monitor immune response through serum testing
Adjust immunisation schedule if needed (flexible)

Testing :

Titer assessment against target antigen
Optional early functional verification (client or CER)

Client involvement :

Review of interim results
Go/No‑Go validation before entering cell fusion or B‑cell selection

Deliverables :

Immunisation report
Serum samples (on request)
Decision on best responder(s)

3. Screening & Candidate Identification (3–6 weeks)

Mouse & Rat — Hybridoma Workflow

Isolation of antibody‑producing cells
Selection of positive wells based on binding activity
Expansion of top candidates
Optional functional screening depending on your application

Rabbit — B‑Cell Workflow

Selection of B‑cells producing high‑affinity antibodies
Direct sequencing of VH/VL regions
Recombinant expression for stable long‑term supply

Testing :

Binding assays (ELISA or application-specific test)
Optional specificity / cross‑reactivity screening
Optional functional testing (client or CER)

Deliverables :

List of positive candidates + performance summary
Recommendation of top candidates to clone/sequence

4. Clonal Selection & Stabilisation (4–8 weeks)

Goal : Obtain a stable, reliable monoclonal antibody source.

What we do :

Clonal isolation (hybridoma) or recombinant expression (rabbit)
Isotyping
Secondary validation of monoclonality & performance
Banking of stable clone(s)

Testing :

Binding confirmation
Application-oriented testing if required (client or CER)

Deliverables :

Purified antibodies from selected clone(s)
Performance summary
Optional sequence data (recombinant formats)
Optional Master Cell Bank creation (covered on another page)

5. Small-Scale Production & Purification (2–4 weeks)

What we do :

Production of mg‑ to multi‑mg batches
Purification adapted to your needs
Optional buffer exchange or conjugation
Optional freeze‑drying (diagnostic-friendly)

Testing :

Concentration, purity, identity
Optional functional/activity/physico-chemical tests : affinity, potency, PTM analysis

Deliverables :

Purified monoclonal antibody (liquid or lyophilised)
Certificate of Analysis
Project summary with performance highlights

6. Optional Progression to Engineering / Biomanufacturing / Preclinical

These steps have their own dedicated pages, but are fully compatible with our monoclonal workflow.

Depending on your needs, we can connect your monoclonal antibody to :

Antibody engineering (reformatting, Fc variants, scFv, chimerisation…)
Biomanufacturing (multi‑gram or routine diagnostic production)
Cryostorage (long-term backup of your clone or sequence)
Preclinical services (in vitro/in vivo models, biodistribution, PoC

Segments We Support

Diagnostic Industry

High‑performance monoclonals adapted to ELISA, CLIA, LFA
Options for lyophilised reagent formats
Smooth transition to routine production

Biotech & R&D

Monoclonals for mechanism‑of‑action, target validation, in vitro screening
Recombinant formats adapted to exploratory or preclinical workflows

Quality, Compliance & Ethics

ISO9001-certified process
In‑house animal facility with strict 3R principles
Confidentiality by design
Full traceability & controlled documentation
Full IP retained by the client

Key Figures (placeholders)

25+ years of antibody development
100,000+ antibody programs across industries
12 animal species on site
Integrated discovery-to-preclinical continuum
ISO9001 certification