The different uses of bioconjugation at the CER Groupe

In the rapidly expanding field of biotechnology, bioconjugation plays a crucial role in creating biomolecules with enhanced and targeted properties. At CER Groupe, we are dedicated to harnessing the full potential of bioconjugation to deliver innovative and high-performance solutions to our industrial and academic partners.

Our bioconjugation services at CER Groupe are fully integrated and benefit from the expertise developed in our core activities, including bioproduction and immunobiological and physicochemical characterization.

With our advanced technology and expertise, we provide high-quality bioconjugation services tailored to the specific needs of each project.

Bioconjugation: Diverse Applications for Tailored Solutions

Bioconjugation involves linking two molecules, at least one of which is a biomolecule, to create conjugates with new or enhanced properties. This technique is essential across various fields, including diagnostics, therapeutics, and biomedical research. At CER Groupe, we utilize multiple bioconjugation approaches, each suited to specific applications:

1. Antibody Conjugation: We perform antibody conjugation with enzymes, fluorophores, or solid supports such as immunoaffinity gels, magnetic beads, or gold nanoparticles to develop ultra-sensitive and specific detection and purification tools. These conjugates are widely used in immunological tests such as immunoprecipitation, ELISA, LFIA, and immunohistochemistry.

1. Biosensor Development: By integrating recognition biomolecules (antibodies, receptors, etc.) onto detection platforms such as biolayer interferometry (BLI), we develop highly sensitive and specific biosensors for applications ranging from medical diagnostics to environmental monitoring.
2. Hapten Coupling: Bioconjugation enables the binding of small molecules, known as haptens, to carrier proteins. These conjugates are used to induce an immune response to obtain targeted antibodies or as reagents in competitive immunoassays, enabling precise detection of small molecules such as toxins and drug residues.
3. Protein and Peptide Conjugation: To stabilize proteins or endow them with new functionalities, we carry out conjugations with polymers, lipids, or other proteins. These conjugates support the development of biomaterials for regenerative medicine, enhanced vaccines, or more stable industrial enzymes.

Cutting-Edge Technology and Expertise for Bioconjugation

At CER Groupe, we leverage state-of-the-art technologies to ensure the quality and effectiveness of our bioconjugation products:

• Specific Conjugation: Our site-specific conjugation techniques, including our patented SugAb technology and click chemistry, allow precise control over the binding site on the biomolecule, ensuring structural preservation, optimal functionality, and high reproducibility of conjugates.
• Formulation Optimization: We provide formulation optimization services, including lyophilization, to ensure the long-term stability of conjugates under various storage and usage conditions.
• Advanced Characterization: With the expertise and equipment in our laboratories, we thoroughly characterize the physicochemical and biochemical properties of bioconjugates, ensuring their quality and performance. Analytical techniques include HRMS, UPLC-MS/MS, BLI, flow cytometry, spectrophotometry, Western Blot, and ELISA.

A Partnership for Innovation and Customer Service

At CER Groupe, we believe in close, collaborative partnerships to innovate and meet tomorrow's challenges. Our bioconjugation services are designed to meet the specific needs of our partners while contributing to a more sustainable biotechnology industry:

• Customized Collaboration: We work closely with our partners to develop tailor-made bioconjugation solutions that meet their specific requirements and scientific and commercial objectives.
• Commitment to R&D: Our continuous investment in research and development enables us to offer cutting-edge solutions while reducing development costs and timelines.

Conclusion

CER Groupe positions itself as a key player in bioconjugation, offering innovative and customized solutions across various biotechnology sectors. Through our expertise, advanced technologies, and commitment to quality and sustainability, we support our partners in realizing their most ambitious projects.

Contact us today to discover how our bioconjugation services can transform your ideas into concrete and effective solutions.