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Immunomonitoring

Integrated in-vitro and in-vivo studies to understand your therapeutic product properties
Home Non-clinical services Immunomonitoring

Understanding immune responses is central to developing vaccines, biologics, ATMPs, medical devices, functional foods, and novel protein ingredients. CER Groupe provides comprehensive, multi‑platform immunomonitoring services combining cellular, humoral, molecular and biomarker analyses across a wide range of animal species and human samples.

As both a Research CenterCenter and CRO, we deliver tailored assay development and validation, regulatory‑aligned data packages, and deep scientific guidance to support programs from discovery to preclinical evaluation. Our immunomonitoring data support critical go/no‑go decisions, mechanism‑of‑action confirmation, and translational risk reduction throughout non‑clinical development.

Our assays are performed within a GLP‑like quality framework ensuring traceability, reproducibility, and regulatory‑ready documentation

Why Choose CER Groupe?

A dual identity: Research CenterCenter + CRO

Bringing together advanced scientific expertise and operational reliability.

Multi-species capabilities (strong differentiator)

Rodents, rabbits, pigs, ruminants and large animals, enabling full translation and species‑specific assay validation.. This multi‑species approach reduces translational uncertainty and supports species‑relevant immunological decision‑making.

Highly customizable assays

Tailored protocols for novel biologics, immune‑modulating therapies, medical implants, vaccine candidates and functional food ingredients.

Regulatory-aligned GLP-like quality

Processes designed for traceability, reproducibility and regulatory‑oriented datasets.

Integrated platforms

Flow cytometry, ELISA/MSD, qPCR, BLI, UHPLC‑FLR/HRMS, cell-based assays, ex vivo stimulation.

Our Immunomonitoring Capabilities

Below is the full scope of services included in this offering.

Cellular Immunology Assays (Flow Cytometry, FACS)

Technologies & analyses:

  • Multicolor flow cytometry (up to 13 colors)
  • T cell subset profiling (CD4+, CD8+, Treg)
  • B cell subset analysis
  • NK cell activity & cytotoxicity
  • Dendritic cell immunophenotyping
  • Myeloid cell characterization (monocytes, macrophages, neutrophils)
  • Cross-species immunophenotyping panels
  • Fluorescence-Activated Cell Sorter (FACS)

Applications:

  • Vaccine immune profiling
  • ATMP / cell therapies
  • Inflammatory response to biomaterials & implants
  • Immunotoxicology screening
  • Mode-of-action studies
Functional Immune Assays

Cellular function readouts:

  • ELISpot (IFN‑γ, IL‑2, IL‑4…)
  • Intracellular cytokine staining (ICS)
  • Lymphocyte proliferation assays (CFSE)
  • Cytotoxicity assays (LDH, MTT, Resazurin)
  • Phagocytosis assays
  • Antigen‑specific T cell response assays
  • Multi-species compatible formats

Applications

  • Vaccine Biologics immunogenicity
  • T cell activation/expansion
  • Assessment of immune stimulants or suppressors
  • Evaluation of novel food or bioactive ingredients inducing immune response
Humoral Immunity & Antibody Analysis

Quantitative & qualitative antibody characterization :

  • Competitive, sandwich and indirect ELISA (Total IgA/IgG/IgM/IgE; antigen‑specific responses)
  • Neutralizing antibody assays
  • Pseudovirus seroneutralization
  • Isotyping & subclass profiling
  • Affinity & avidity (BLI)
  • Multiplex antibody/cytokine detection (MSD)
  • Dextramer staining

Applications :

  • Vaccine Aantibody responses
  • Biologics development and lead optimization
  • Food allergens, novel proteins, functional ingredients characterization in support of safety, allergenicity and regulatory assessment.
  • Comparative immunogenicity across species
  • Anti- drug antibody (ADA) detection
Cytokines & Biomarker Profiling

Platforms :

  • Multiplex cytokine and chemokine panels (MSD)
  • Growth factors quantification 
  • Soluble checkpoint/activation marker quantification 
  • Single cytokine ELISA
  • Total & specific protein quantification

Applications :

  • Early inflammatory signatures
  • Implant/tissue-material biocompatibility
  • Immune activation triggered by novel foods
  • Mechanistic understanding for biologics
Molecular Immunomonitoring

Gene expression profiling

  • PCR & qPCR immune gene panels
  • Targeted expression of cytokines, chemokines, immune receptors
  • Custom gene panels on request

Applications

  • Mechanism-of-action elucidation
  • Vaccine signature profiling
  • Immune tolerance or autoimmunity markers
  • Response to dietary bioactives
Specialized Assays

Advanced expertise

  • Ex vivo stimulation on whole blood, PBMCs, splenocytes, bone marrow, lymph nodes
  • Custom assay development for immune-modulating compounds
  • Vaccine immunogenicity & potency assays
  • Immune tolerance & autoimmunity evaluation
  • Anti-drug antibody (ADA) assays
  • Glycosylation profiling (UHPLC-FLR/HRMS)
Serum & Plasma Biomarkers
  • C‑reactive protein (CRP)
  • Immune complex detection
Functional Assays for Therapeutics
  • ADCC (antibody-dependent cell-mediated cytotoxicity)
  • CDC (complement-dependent cytotoxicity)
  • Fc‑mediated antibody functions
  • Cytokine release assays for biologics
  • Treg suppression assays
  • Checkpoint inhibitor functional assays

Industry Segments Supported

Biopharma & Biotech

Vaccines, monoclonal antibodies, cytokines, fusion proteins, ATMPs, immune modulators, biosimilars.

Medtech (Implantables)

Characterization of inflammatory response, biocompatibility‑related immune profiling, long‑term immune activation signature.

Agrifood & Novel Proteins

Allergenicity, immunogenicity, functional ingredient characterization, novel protein sources. Studies designed to address regulatory, safety and scientific assessment requirements.

Diagnostics

Assay development, reference material characterization, validation support.

Quality & Regulatory Framework

  • GLP-like quality system across platforms
  • Traceability of samples, reagents, panels and results
  • Regulatory‑aligned data outputs
  • Scientific documentation suitable for regulatory submissions, due diligence packages, or partner evaluation

Collaboration Workflow

  1. Project definition Objectives, species, sample types, immunological endpoints, regulatory needs.
  2. Assay design Standard methods or custom developments.
  3. Execution in GLP-like environment Validated protocols and controlled documentation.
  4. Data analysis Biostatistics, interpretation, comparative analysis across groups/species.
  5. Reporting Comprehensive, publication-grade report with raw data on request.

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